Dosage protocol · Metabolic & Weight Loss
AOD-9604 2 mg
Typical daily range: 300–500 mcg once daily (gradual titration).
- Reconstitute: Add 3.0 mL bacteriostatic water → ~0.667 mg/mL (667 mcg/mL) concentration.
- Typical daily range: 300–500 mcg once daily (gradual titration).
- Easy measuring: At 0.667 mg/mL, 1 unit = 0.01 mL ≈ 6.67 mcg on a U‑100 insulin syringe.
- Storage: Lyophilized: freeze at −20 °C (−4 °F); after reconstitution, refrigerate at 2–8 °C (35.6–46.4 °F); avoid freeze–thaw cycles.
BAC water3.0mL
Concentration0.667mg/mL
Reconstitution
AOD-9604 dosage chart
AOD-9604 dosage chart
| Week | Dose | Draw |
|---|---|---|
| Weeks 1–4 | 300 mcg | 45 units0.45 mL |
| Weeks 5–12 | 500 mcg | 75 units0.75 mL |
How much to draw
The Draw column shows exactly where to stop on a U-100 insulin syringe. Different vial size or dose? The calculator below recomputes it live.
Supplies needed
Supplies needed
Peptide vial
The lyophilized compound
Bacteriostatic water
For reconstitution
U-100 insulin syringes
One per injection
Alcohol swabs
Stopper + site each time
How it works
AOD-9604 is a synthetic 16-amino-acid peptide fragment derived from the C-terminal region of human growth hormone, often written in the literature as Tyr-hGH177-191.[2] It was designed to isolate growth hormone's fat-metabolism effects from its broader growth-promoting and glucose-related actions, with the goal of finding an obesity treatment without the risks associated with full growth hormone therapy.
The compound is also written as AOD9604 or AOD 9604 in different sources, and appears in both a free-base and an acetate salt form in regulatory documents. It is not equivalent to, or a safer substitute for, approved growth hormone products such as somatropin, which have their own distinct FDA-approved indications and warnings.
Benefits & side effects
AOD-9604's human evidence is more extensive than most research peptides, but ultimately disappointing for its intended use. Six randomized, placebo-controlled trials involving 893 adults evaluated intravenous and oral dosing, and a 12-week study using 1 mg/day reportedly showed modestly greater weight loss than placebo in early summaries.[2]
However, the pivotal 24-week OPTIONS study, which enrolled more than 500 adults with obesity under a formal diet-and-exercise program, did not show a statistically significant weight-loss difference versus placebo at its primary endpoint. FDA reviewers concluded in 2024 that the available data did not support AOD-9604's effectiveness for obesity by any route of administration.[1] Broader online claims about muscle preservation, anti-aging, or performance benefits are not supported by controlled human trials.
Calculator
Plan your own dose
Reconstituting a different vial size or targeting a different dose? Run the numbers.
1
Reconstitution
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