Evidence & concentration worksheet · Bioregulators
Cortagen 20 mg
Human efficacy and a validated dose have not been established for this compound. The former regimen has been withheld; only concentration arithmetic remains available.
Evidence review
No established human dosing protocol
Human efficacy and a validated dose have not been established for this compound. The former regimen has been withheld; only concentration arithmetic remains available.
How it works
Cortagen is the experimental tetrapeptide AEDP, marketed as a brain-cortex “bioregulator.” It is distinct from Cortexin, a heterogeneous animal-tissue extract, and has no FDA-approved product or indication.
Benefits & side effects
Studies have examined Cortagen-related gene-expression changes in mice and sciatic-nerve regeneration in rats.[1][2] These models do not establish cognitive benefit, stroke recovery, neuroprotection, anxiety treatment, nerve repair, or anti-aging effects in people.
Calculator
Concentration and measurement calculator
Use this only to check arithmetic from an authoritative product label, registered study protocol, or qualified clinician.
Arithmetic only — not a dose recommendation
Enter only a concentration and target supplied by an authoritative product label, a registered study protocol, or a qualified clinician. A correct conversion does not establish that a substance, vial, route, or dose is safe or effective.
Enter only a concentration and target supplied by an authoritative product label, a registered study protocol, or a qualified clinician. A correct conversion does not establish that a substance, vial, route, or dose is safe or effective.
Source concentration
Source-supplied target
References
References
- Neuroendocrinology Letters — Cortagen and gene expression in mouse heart (2004)
- Bulletin of Experimental Biology and Medicine — Effect of Cortagen on sciatic-nerve regeneration in rats (2000)
- U.S. FDA — Understanding the risks of compounded drugs (2026)