Dosage protocol · Brain Health & Nootropics
DSIP 5 mg
Typical daily range: 100–300 mcg once daily (gradual titration); advanced up to 500 mcg.
- Reconstitute: Add 3.0 mL bacteriostatic water → ~1.67 mg/mL concentration.
- Typical daily range: 100–300 mcg once daily (gradual titration); advanced up to 500 mcg.
- Easy measuring: At 1.67 mg/mL, 1 unit = 0.01 mL ≈ 16.7 mcg on a U-100 insulin syringe.
- Storage: Lyophilized: freeze at −20 °C (−4 °F); after reconstitution, refrigerate at 2–8 °C (35.6–46.4 °F); avoid freeze–thaw cycles.
BAC water3.0mL
Concentration1.67mg/mL
Reconstitution
DSIP dosage chart
DSIP dosage chart · 1
| Week | Dose | Draw |
|---|---|---|
| Week 1 | 100 mcg | 6 units0.06 mL |
| Week 2 | 150 mcg | 9 units0.09 mL |
| Week 3 | 200 mcg | 12 units0.12 mL |
| Weeks 4–8 | 250–300 mcg | 15–18 units0.18 mL |
DSIP dosage chart · 2
| Week | Dose | Draw |
|---|---|---|
| Week 5 | 350–400 mcg | 21–24 units0.24 mL |
| Weeks 6–8+ | 400–500 mcg | 24–30 units0.30 mL |
How much to draw
The Draw column shows exactly where to stop on a U-100 insulin syringe. Different vial size or dose? The calculator below recomputes it live.
Supplies needed
Supplies needed
Peptide vial
The lyophilized compound
Bacteriostatic water
For reconstitution
U-100 insulin syringes
One per injection
Alcohol swabs
Stopper + site each time
How it works
DSIP, or delta sleep-inducing peptide, is a small nonapeptide, built from nine amino acids, first reported in a 1977 paper describing a substance isolated from rabbit cerebral venous blood that appeared to trigger delta-wave EEG activity associated with deep sleep.[2] PubChem lists it as a defined chemical entity, but reviewers note that "DSIP-like immunoreactivity" detected in later assays may sometimes reflect related fragments rather than the intact peptide, complicating the broader literature.[3]
Despite its name, DSIP is not an established sleep medication. It remains primarily a decades-old research subject rather than a compound with a modern, well-characterized clinical profile.
Benefits & side effects
The original evidence for DSIP comes from rabbit and rat studies examining EEG delta-wave activity and sleep-stage changes.[2] Human research followed, but consists mainly of small, older pilot and double-blind studies measuring sleep latency, sleep efficiency, and subjective sleep quality in people with poor sleep or chronic insomnia; a 1986 review described the findings as inconsistent and hard to generalize.[3]
A search of ClinicalTrials.gov shows no modern, large-scale DSIP trial program, which limits confidence in current claims.[7] DSIP has also been explored in older, exploratory literature on cortisol and growth hormone signaling, pain, and opioid withdrawal, but these remain mechanistic or anecdotal.[3] Popular online claims that DSIP promotes lucid dreaming are not supported by any identified clinical evidence.
Calculator
Plan your own dose
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