Dosage protocol · Hormonal & Sexual Health
Gonadorelin 2 mg
Typical dose range: 50–250 mcg per injection, 2–3 times weekly.
- Reconstitute: Add 2.0 mL bacteriostatic water → 1 mg/mL concentration (1000 mcg/mL).
- Typical dose range: 50–250 mcg per injection, 2–3 times weekly.
- Easy measuring: At 1 mg/mL, 1 unit = 0.01 mL = 10 mcg on a U‑100 insulin syringe.
- Storage: Lyophilized: store at −20 °C (−4 °F); after reconstitution, refrigerate at 2–8 °C (35.6–46.4 °F); avoid freeze–thaw cycles.
BAC water2.0mL
Concentration1mg/mL
Per unit (0.01 mL)10mcg
Reconstitution
Gonadorelin dosage chart
Gonadorelin dosage chart · 1
| Week | Dose | Draw |
|---|---|---|
| Weeks 1–2 (Initiation) | 50 mcg | 5 units0.05 mL |
| Weeks 3–4 (Titration) | 100 mcg | 10 units0.10 mL |
| Weeks 5–8 (Maintenance) | 100–150 mcg | 10–15 units0.15 mL |
Gonadorelin dosage chart · 2
| Week | Dose | Draw |
|---|---|---|
| Days 1–7 (Burst) | 200 mcg | 20 units0.20 mL |
| Days 8–14 (Taper) | 100 mcg | 10 units0.10 mL |
| Week 3+ (Optional Maintenance) | 100 mcg 2–3×/wk | 10 units0.10 mL |
How much to draw
The Draw column shows exactly where to stop on a U-100 insulin syringe. Different vial size or dose? The calculator below recomputes it live.
Supplies needed
Supplies needed
Peptide vial
The lyophilized compound
Bacteriostatic water
For reconstitution
U-100 insulin syringes
One per injection
Alcohol swabs
Stopper + site each time
How it works
Gonadorelin is the synthetic form of gonadotropin-releasing hormone (GnRH), a 10-amino-acid peptide (decapeptide) that matches the hormone naturally released by the hypothalamus.[1] It appears in different salt forms -- gonadorelin hydrochloride, acetate, and diacetate -- which are generally the same active peptide with different formulation chemistry.[2]
Gonadorelin is meaningfully different from long-acting GnRH analogs such as leuprolide. Gonadorelin is designed to reproduce the body's short, pulsatile GnRH signal, while continuous exposure to long-acting GnRH agonists is used clinically to suppress reproductive hormone production through receptor desensitization -- essentially the opposite therapeutic goal.[6][17]
Benefits & side effects
Gonadorelin's best-established human use is diagnostic: a single injection can test whether the anterior pituitary is capable of releasing LH in response to GnRH stimulation, which is the basis of its approved labeling.[3][4] Beyond diagnosis, pulsatile gonadorelin therapy has been studied under specialist supervision in select reproductive endocrine disorders -- congenital or idiopathic hypogonadotropic hypogonadism in men, and functional hypothalamic amenorrhea in women -- where it can help restore more physiologic LH and FSH signaling when the pituitary and gonads remain capable of responding.[8][11]
These findings do not generalize to men on testosterone replacement therapy who hope gonadorelin will reliably preserve fertility, or to broader claims about hormone "optimization," libido, or anti-aging. Exogenous testosterone suppresses spermatogenesis through a separate pathway, and current endocrine and urology guidelines do not establish gonadorelin as a routine fix for that suppression.[18][19]
Calculator
Plan your own dose
Reconstituting a different vial size or targeting a different dose? Run the numbers.
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Reconstitution
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