Encyclopedia · Longevity & Mitochondrial Health

NAD+

Evidence review

Evidence grade C

Small, dated, or methodologically limited human studies exist, but they do not establish a reliable clinical benefit, safety profile, or standard dose.

Reviewed Aug 10, 2026 3 linked authoritative sources

Nicotinamide adenine dinucleotide (NAD+) is a nucleotide-derived cellular coenzyme, not a peptide. It participates in redox reactions and enzyme signaling. Essential biology does not by itself show that intravenous NAD+ improves energy, cognition, addiction, longevity, recovery, or wellness.

NAD+ is not a peptide

Nicotinamide adenine dinucleotide (NAD+) is a nucleotide-derived cellular coenzyme, not a peptide. It participates in redox reactions and enzyme signaling. Essential biology does not by itself show that intravenous NAD+ improves energy, cognition, addiction, longevity, recovery, or wellness.

Direct IV evidence is extremely limited

A 2019 pilot followed the NAD+ metabolome during a six-hour intravenous infusion; it was designed around metabolism and tolerability, not controlled proof of clinical benefit.[1] A 2026 retrospective real-world pilot compared infusion tolerability rather than establishing efficacy.[2] Human studies of oral precursors such as nicotinamide riboside or nicotinamide mononucleotide test different substances and routes and cannot validate IV NAD+ clinic claims.

Safety and quality gaps

Published IV studies are too small to define uncommon events, long-term outcomes, interactions, pregnancy use, or benefits. Intravenous administration also adds line, infection, contamination, dosing, and infusion-reaction risks. Compounded drugs are not FDA-approved or premarket-verified for safety, effectiveness, or quality.[3]

Regulatory status

There is no FDA-approved IV NAD+ product for anti-aging, wellness, fatigue, cognition, addiction treatment, or recovery. Teloryx does not publish an infusion dose, rate, schedule, or preparation recipe.

Evidence review

Sources and evidence

Citation numbers in the article link to the exact regulator records, trial registrations, and publications reviewed.

  1. Frontiers in Aging NeurosciencePilot metabolome study during a six-hour intravenous NAD+ infusion (2019)
  2. Frontiers in AgingRetrospective tolerability pilot of intravenous NAD+ and nicotinamide riboside (2026)
  3. U.S. FDAUnderstanding the risks of compounded drugs (2026)