Encyclopedia · Hormonal & Sexual Health

Kisspeptin

Evidence review

Evidence grade B

Controlled human trials exist, but the compound remains investigational and has no approved consumer product.

Reviewed Aug 10, 2026 4 linked authoritative sources

Kisspeptins are peptides produced from the KISS1 gene that activate the KISS1 receptor upstream of gonadotropin-releasing hormone. Kisspeptin-54 and kisspeptin-10 are distinct research forms; findings about one formulation and study design cannot automatically be assigned to an online vial of the other.

What kisspeptin is

Kisspeptins are peptides produced from the KISS1 gene that activate the KISS1 receptor upstream of gonadotropin-releasing hormone. Kisspeptin-54 and kisspeptin-10 are distinct research forms; findings about one formulation and study design cannot automatically be assigned to an online vial of the other.

Human evidence exists in monitored fertility research

In a 53-participant clinical study, kisspeptin-54 triggered egg maturation during IVF.[1] A later phase 2 open-label randomized dose-finding study in 60 women at high risk of ovarian hyperstimulation syndrome reported oocyte maturation and no moderate, severe, or critical OHSS in that study.[2]

These are promising specialist fertility findings, not proof of general fertility enhancement, testosterone optimization, libido treatment, anti-aging effects, or safe unsupervised use. They were conducted within tightly monitored IVF protocols and do not create a consumer dose.

Kisspeptin-10 has additional compounding concerns

FDA's compounding review identifies safety and immunogenicity concerns for kisspeptin-10 and notes that subcutaneous administration may pose significant risk.[3] That concern does not erase the kisspeptin-54 research, but it reinforces that isoform, formulation, route, manufacturing quality, and monitoring matter. No FDA-approved label defines contraindications, interactions, pregnancy use, or long-term repeated-use safety.

Compounded drugs are not FDA-approved or premarket-verified for safety, effectiveness, or quality.[4]

Regulatory status

Kisspeptin remains investigational in the United States; there is no FDA-approved kisspeptin product or prescribing label. Teloryx shows the human trials as research context only and does not publish a kisspeptin dose, cycle, or reconstitution recipe.

Evidence review

Sources and evidence

Citation numbers in the article link to the exact regulator records, trial registrations, and publications reviewed.

  1. Journal of Clinical InvestigationKisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization (2014)
  2. Journal of Clinical Endocrinology & MetabolismKisspeptin-54 to trigger oocyte maturation in women at high risk of OHSS (2015)
  3. U.S. FDAPharmacy Compounding Advisory Committee review of kisspeptin-10 (2026)
  4. U.S. FDAUnderstanding the risks of compounded drugs (2026)